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TIXiMED, Inc. is focused on developing and commercializing TXNIP inhibiting medication as a first-of-its-kind oral therapeutic for Type 1 and Type 2 diabetes. TIXiMED is the exclusive license holder for the patent (composition of matter and method of use) surrounding TIX100, a novel small molecule that normalizes pancreatic beta cell TXNIP, a detrimental protein elevated in Type 1 and Type 2 diabetes. Increased TXNIP causes pancreatic islet dysfunction and death of insulin-producing beta cells and thereby contributes to the development and progression of diabetes. Diabetes affects more than half a billion people worldwide. Those affected by Type 1 diabetes are dependent on multiple daily insulin injections or continuous insulin infusions to stay alive and manage their blood sugar. Oral anti-diabetic drugs are only approved for Type 2 diabetes, but can be associated with multiple side effects, underlining the need for novel and better oral diabetes medications for Type 1 and Type 2 diabetes. TXNIP inhibition has recently been demonstrated to be an effective and safe therapeutic approach in adults and children with recent onset Type 1 diabetes and TIX100 shows beneficial, anti-diabetic effects in 4 different mouse models. Advantages of TIX100 include oral availability, no associated hypoglycemia or weight gain, potent inhibition of detrimental TXNIP in human islets, and a favorable pharmacokinetic and safety profile. In addition, TIX100 inhibits excessive glucagon secretion and hepatic glucose production and protects against fatty liver. Thus, TIX100 holds promise for durable, weight-neutral improvement in glycemic control in Type 1 and Type 2 diabetes by targeting common underlying pathology and promoting patients own islet cell health.
Color Pigments Mfrs Assn Inc is a Alexandria, VA-based company in the Business Services sector.
Cote-Reco Inc is a Deschaillons-Sur-Saint-Laurent, QC-based company in the Business Services sector.
Over the past decade, Tin Fulton Walker & Owen has emerged as one of North Carolinas leading law firms, a multi-faceted group of attorneys capable of handling all manner of cases across the state. With offices in Charlotte, Chapel Hill, and Raleigh, the firm represents clients in criminal and civil matters in both state and federal courts. The lawyers at the firm, many of whom are recognized in peer-reviewed surveys as elite litigators in their respective fields, are highly respected and experienced advocates who have handled some of the most challenging and difficult cases. The firm began in 2002 when Noell Tin hired Missy Owen to help him with a bustling criminal practice. A few years later, Matthew Pruden joined the firm as its client base continued to grow. The firm expanded into civil litigation in 2006 with the addition of former Chief Resident Superior Court Judge Shirley Fulton and, soon thereafter, civil practitioner Nancy Walker. In the fall of 2008, the firm relocated from uptown Charlotte to the historic Villalonga house in Dilworth. The firm has since become home to Margaret Errington, John Gresham, Luke Largess, William Simpson, Adam Stein, Jake Sussman and Jon Wallas; all former members of the historic civil rights firm Ferguson Stein Chambers Gresham & Sumter, where Tin first got his start as a young lawyer. In 2013, Sam McGee and former Special Superior Court Judge Lane Williamson joined the Charlotte office, bringing extensive trial experience in complex civil litigation and business matters. In 2015, criminal defense specialist Mike Klinkosum opened the firms Raleigh office. He was later joined by Emily Gladden, who also focuses on criminal defense. The firms current practice areas include Criminal Defense, White Collar Defense, Personal and Catastrophic Injury, Medical Negligence, Nursing Home Abuse and Neglect, Employment and Labor, Civil Rights and Constitutional Law, Professional Liability, and Business Litigation.
All Star Cleaning Service Inc is a Denver, CO-based company in the Business Services sector.